Psilocybin, A New Frontier in Depression Treatment

May 31, 2023
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In the quest for effective treatments for depression, a surprising candidate has emerged from the realm of psychedelic substances. Psilocybin, the active compound in magic mushrooms, is showing promising results in clinical trials, potentially rivaling traditional antidepressants.

The Psilocybin Promise

The Centre for Psychedelic Research at Imperial College London conducted a rigorous trial comparing the therapeutic potential of psilocybin with a leading antidepressant, escitalopram. The study involved 59 participants with moderate-to-severe depression, who underwent two sessions of psilocybin therapy or a six-week course of escitalopram.

The results, published in the New England Journal of Medicine, revealed that while both groups experienced reduced depression scores, the reductions occurred more quickly and were greater in magnitude in the psilocybin group. However, the researchers caution that the main comparison between psilocybin and the antidepressant was not statistically significant, indicating the need for larger trials over a longer period.

Psilocybin Therapy: A New Approach

Unlike traditional antidepressant treatment, psilocybin therapy involves a unique combination of drug administration and psychological support. Participants received an oral dose of psilocybin in a specialist clinical setting, accompanied by a curated music playlist and guidance from a psychological support team.


This approach showed marked improvements across a range of subjective measures, including the ability to feel pleasure, express emotions, and increased feelings of wellbeing. Furthermore, greater reductions in anxiety and suicidal ideation were observed in the psilocybin group.

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A Head-to-Head Comparison

The study design allowed for a direct comparison between psilocybin and a traditional SSRI antidepressant. The psilocybin group received a high dose of the substance and a placebo, while the escitalopram group received a very low dose of psilocybin and the antidepressant.

The results showed that 70% of people in the psilocybin group responded to the treatment, compared with 48% in the escitalopram group. Moreover, remission of symptoms was seen in 57% of the psilocybin group, compared with just 28% in the escitalopram group.

Caution and Future Directions

Despite the encouraging findings, the researchers urge caution. They warn against self-medication with psilocybin, emphasizing the importance of the clinical and therapeutic context provided in the trial. They also highlight the need for further trials to confirm these findings and potentially lead to psilocybin becoming a licensed medicine.

The research on psilocybin therapy for depression is still in its early stages, but the results so far are promising. As we continue to explore new frontiers in mental health treatment, psilocybin may well become a key player in the fight against depression. However, as with all new treatments, it is essential to proceed with caution, ensuring rigorous testing and careful consideration of potential risks and benefits.

Click on this link to read this article in French version

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